Its weight-management evidence comes largely from the SURMOUNT trial program published in The New England Journal of Medicine in 2022, with SURMOUNT-OSA extending the data to obstructive sleep apnea in 2024
But they are part of two different classes of drugs, and its considered generally safe to take them together
The side effects and medication descriptions are simplified and made clearer, if needed
Importantly, IGF-I and its binding proteins exert acute anabolic effects on metabolism as well as mediating myoblast proliferation, differentiation, and apoptosis[2]
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